- hepatectomy safety - transplant - portal flow physiology - ALPPS - small-for-size syndrome - chemotherapy injury - nutrition - sarcopenia - portal hypertension ### Factors That Impair Regeneration - steatosis / NASH - cirrhosis - chemotherapy injury - portal hypertension - cholestasis - malnutrition / sarcopenia - sepsis - ischemia-reperfusion injury ### Factors That Support Regeneration - adequate portal inflow - preserved venous outflow - nutrition and protein repletion - exercise / metabolic optimization - staged hypertrophy strategies Then maybe: - caloric/protein goals - role of enteral nutrition - frailty/sarcopenia